Journal Reviews

Neuro-Ophthalmology journal cover image

Sub-clinical detection methods in multiple sclerosis

3 April 2023 | | Neuro-Ophthalmology | Subclinical multiple sclerosis, axonal degeneration, frequency-doubling perimetry, optic neuritis, optical coherence tomography, standard automated perimetry

Visually symptomatic multiple sclerosis (MS) provides only part of the required information to assist in understanding the disease. Recently, researchers have concentrated their efforts on diagnosing MS cases in the subclinical period. The aim of this paper was to assess...

Transient thickening of the macular retinal nerve fibre layer in acute optic neuritis

1 December 2022 | | Neuro-Ophthalmology | Optic neuritis, axonal degeneration, neurofilament protein, retina, tissue

Acute optic neuritis (ON) causes axonal degeneration, which can be quantified from the blood by neurofilament protein (Nf) levels. Within about three months, atrophy of the retinal nerve fibre layer (RNFL) follows. However, it remains challenging to explain why there...